I haven't done it but I do read the Bioware forums every day. ME on the HDD won't totally change the game. It will help some, but don't expect the elevators to move ANY faster... (mainly, it'll only eliminate the occasional 'loading' pause when running from place to place) Most of the issues seem to be the engine itself---it just can't handle that many textures or something. (I swear it was designed only for FPS in desolate apocalpytic games, where they only need 4 textures---brown stuff, grey stuff, player, and alien bug)