And this really works with the fact that Sheryl was the 8th or 9th (don't recall, too lazy to go back and look), Fairy, was it? It sure sounded like they were running experiments on several subject, Sheryl not being the first.
I think that's looking way too much into it. They revealed her to be a random homeless girl, I think going back at this point would be silly. I'm thankful they went this route, otherwise this would all be a bit ridiculous and silly.
I don't imagine this current incarnation of Batman will go on long enough to see the character return. There are too many villains for them to bring into the reborn franchise before revisiting Two Face. I'm sticking with no.
Except we've seen another Macross class vessel in Frontier. I am assuming if they built a second one they have full working knowledge of the original.
But, once again, Sharon Apple had an effect on people before she got anywhere near Earth.